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KMID : 0378019690120070035
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New Medical Journal
1969 Volume.12 No. 7 p.35 ~ p.36
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Treatment of Burn
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朴龍喆/Park, Y. C.
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Abstract
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This study was directed to obtain the glomerular filtration rate in toxemia of pregnancy by the method of endogenous creatinine clearance and the relation with its clinical symptoms.
The material was obtained from 49 toxemic pregnant women in the ward and outpatient clinics, Dept. of Ob. & Gyne., S. N. U. H., who visited with complaints of albuminuria, edema and hypertension, and from 30 normal control group.
Quantitative calculation of serum and urine creatinine was performed by the standard method of clinical chemistry reported in Academic Press.
All analysis were performed in duplication. The results were as follows;
1. Between control group and mild cases of toxemic pregnant women, each mean of urinary creatinine excretion, serum creatinine concentration, and endogenous creatinine clearance was not considerably different. In severe cases group of toxemic pregnant women, however, serum creatinine concentration raised significantly more than control group and mild cases group of toxemic pregnant women, and endogenous creatinine clearance dropped considerably, and also it was observed that glomerular filtration rate was proportionally decreased according to the severity of toxemia.
2. In toxemia group, there seems to be no relation between urinary creatinine excretion and serum creatinine concentration.
3. In severe cases, dropping of endogenous creatinine clearance tends to lead slightly to decrease of creatinine excretion.
4. Retention of serum creatinine concentration appears to Iead to decline of endogenous creatinine clearance. Hyperbolic relationship between them was observed.
5. The comparison of creatinine clearance of severe cases group of toxemic pregnant women with its clinical symptomatoiogy may be worthwhile to point out as´ follows;
i. There is no relation between blood pressure and endogenous creatinine clearance.
ii. Severity of edema correlates to degree of a decline of endogenous creatinine clearance.
iii. Endogenous creatinine clearance is proportionally decreased according to the severity of proteinuria.
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KEYWORD
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